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Gastroenterology
Ten-year experience of esophageal endoscopic submucosal dissection of superficial esophageal neoplasms in a single center
Hyung Chul Park, Do Hoon Kim, Eun Jeong Gong, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Ho Kim
Korean J Intern Med. 2016;31(6):1064-1072. Published online September 13, 2016
Background/Aims: Endoscopic submucosal dissection (ESD) of a superficial esophageal neoplasm (SEN) is a technically difficult procedure. We investigated the clinical outcomes of ESD to determine its feasibility and effectiveness for the treatment of SEN.
Methods: Patients who underwent ESD for SEN ..
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Gastric cancer and family history
Yoon Jin Choi, Nayoung Kim
Korean J Intern Med. 2016;31(6):1042-1053. Published online November 1, 2016
Gastric cancer is associated with high morbidity and mortality rates worldwide. Identifying individuals at high risk is important for surveillance and prevention of gastric cancer. Having first-degree relatives diagnosed with gastric cancer is a strong and consistent risk factor for gastric cancer, ..
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Nephrology
Clinical value of pathologic examination of non-neoplastic kidney in patients with upper urinary tract malignancies
Jee Wan Wee, Hye Ran Kang, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, So-Young Jin, Won Jae Yang, Hyunjin Noh
Korean J Intern Med. 2016;31(4):739-749. Published online May 30, 2016
Background/Aims: While surgical resection remains the standard of care in the treatment of upper urinary tract malignancies, nephrectomy is a risk factor for the development of chronic kidney disease (CKD). The aim of this study was to determine whether histologic evaluation of non-neoplastic kidney..
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Gastroenterology
Is height a risk factor for colorectal adenoma?
Jeung Hui Pyo, Sung Noh Hong, Byung-Hoon Min, Dong Kyung Chang, Hee Jung Son, Poong-Lyul Rhee, Jae J. Kim, Young-Ho Kim
Korean J Intern Med. 2016;31(4):653-659. Published online December 23, 2015
Background/Aims: Although it is generally known that the risk for all types of cancer increases with adult height, combined and for several common site-specific cancers (including colon and rectal), evidence is limited for adenomas, which are precursors to colorectal cancer. We evaluated the associa..
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Cardiology
Pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity
Woo-Baek Chung, Ho-Joong Youn
Korean J Intern Med. 2016;31(4):625-633. Published online July 1, 2016
Cardiotoxicity is a well-known complication following treatment with anthracyclines. However, they are still widely used in chemotherapy for breast cancer, lymphoma, leukemia, and sarcoma, among others. Patient clinical characteristics, such as age, sex, comorbidities, anthracycline dose and infusio..
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Trastuzumab-associated autoimmune thyroid disease in a patient with metastatic breast cancer
Hong Ki Min, In-Ho Kim, Jae Young Kim, Tae-hyun Ban, Kyung Hoon Kim, Jeonghoon Ha, Jung-Hoon Kim
Korean J Intern Med. 2016;31(3):608-611. Published online February 18, 2016
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Hemato-oncology
Induction chemotherapy in head and neck squamous cell carcinoma of the paranasal sinus and nasal cavity: a role in organ preservation
Chan-Young Ock, Bhumsuk Keam, Tae Min Kim, Doo Hee Han, Tae-Bin Won, Se-Hoon Lee, J. Hun Hah, Tack-Kyun Kwon, Dong-Wan Kim, Dong-Young Kim, Chae-Seo Rhee, Hong-Gyun Wu, Myung-Whun Sung, Dae Seog Heo
Korean J Intern Med. 2016;31(3):570-578. Published online March 15, 2016
Background/Aims: The role of induction chemotherapy (IC) for eyeball preservation has not been established in head and neck squamous cell carcinoma (HNSCC) of the paranasal sinus and nasal cavity (PNSNC). Periorbital involvement frequently leads to eyeball exenteration with a margin of safety. We ev..
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Paraneoplastic dermatomyositis presenting myopathy combined with synchronous cervical and sigmoid colon cancer
Jae Heun Chung, Min Wook So, Seong-Geun Kim
Korean J Intern Med. 2016;31(2):413-416. Published online January 29, 2016
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Gastroenterology
Synchronous second primary cancers in patients with squamous esophageal cancer: clinical features and survival outcome
Jin Seo Lee, Ji Yong Ahn, Kee Don Choi, Ho June Song, Yong Hee Kim, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Sook Ryu, Sung-Bae Kim, Jong Hoon Kim, Seung-Il Park, Kyung-Ja Cho, Jin-Ho Kim
Korean J Intern Med. 2016;31(2):253-259. Published online February 11, 2016
Background/Aims: Unexpected diagnosis of synchronous second primary cancers (SPC) complicates physicians’ decision-making because clinical details of squamous esophageal cancer (EC) patients with SPC have been limited. We evaluated clinical features and treatment outcomes of patients with synchron..
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Infectious diseases
Risk factors and etiology of surgical site infection after radical neck dissection in patients with head and neck cancer
So Yeon Park, Mi Suk Kim, Joong Sik Eom, Jin Seo Lee, Young Soo Rho
Korean J Intern Med. 2016;31(1):162-169. Published online December 28, 2015
Background/Aims: Surgical site infection (SSI) is a major complication after radical neck dissection (RND) in patients with head and neck cancer (HNC). We investigated the incidence, risk factors, and etiology of SSI among patients who underwent RND.
Methods: A retrospective cohort study was perfor..
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Hemato-oncology
Evaluation of treatment response and tissue necrosis as prognostic indicators following neoadjuvant chemoradiotherapy in rectal cancer patients
Ji-Han Jung, Ho Jung An, Hyung-Jin Kim, Jonghoon Lee, Kang-Moon Lee, Sung Hwan Kim, Hyeon-Min Cho, Byoung Yong Shim
Korean J Intern Med. 2016;31(1):134-144. Published online December 28, 2015
Background/Aims: The objective of this study was to assess the prognostic roles of treatment response and tissue necrosis after chemoradiotherapy (CRT) in locally advanced rectal cancer.
Methods: A total of 243 patients with locally advanced rectal cancer who underwent neoadjuvant CRT were included..
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Long-term survival after concurrent chemoradiation therapy for esophageal cancer with tracheal
invasion
Joon Hyun Cho, Tae Nyeun Kim
Korean J Intern Med. 2015;30(6):931-933. Published online October 30, 2015
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Gastroenterology
Is screening and surveillance for early detection of gastric cancer needed in Korean Americans?
Gwang Ha Kim, Sung Jo Bang, Alexander R. Ende, Joo Ha Hwang
Korean J Intern Med. 2015;30(6):747-758. Published online October 30, 2015
The incidence rate of gastric cancer in Korean Americans is over five times higher than that in non-Hispanic whites, and is similar to the incidence of colorectal cancer in the overall United States population. In Korea, the National Cancer Screening Program recommends endoscopy or upper gastrointes..
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Rheumatology
Allopurinol hypersensitivity syndrome in patients with hematological malignancies: characteristics and clinical outcomes
Hong Ki Min, Boin Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Young Min Park, Sung-Hwan Park
Korean J Intern Med. 2015;30(4):521-530. Published online June 29, 2015
Background/Aims: Allopurinol is a urate-lowering agent that is commonly used to prevent chemotherapy-related hyperuricemia. Allopurinol hypersensitivity syndrome (AHS) is a disorder involving multiple organs, which may be accompanied by cutaneous adverse reactions. We identified the characteristics ..
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Pulmonology
Clinical outcomes of extracorporeal membrane oxygenation support in patients with hematologic malignancies
Hye Seon Kang, Chin Kook Rhee, Hea Yon Lee, Young Kyoon Kim, Soon Seog Kwon, Seok Chan Kim, Jong Wook Lee
Korean J Intern Med. 2015;30(4):478-488. Published online June 29, 2015
Background/Aims: The clinical outcomes of patients with hematologic malignancies who were treated with extracorporeal membrane oxygenation (ECMO) after the failu re of optimal conventional therapy were determined.
Methods: The medical records of all patients administered ECMO during their stay in a..
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Gastroenterology
Roadmap for elimination of gastric cancer in Korea
David Y. Graham
Korean J Intern Med. 2015;30(2):133-139. Published online February 27, 2015
Most gastric cancers are caused by infection with the common human bacterial pathogen, Helicobacter pylori. It is now accepted that gastric cancer can be prevented and virtually eliminated by H. pylori eradication and this knowledge was responsible for country-wide H. pylori era..
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Hemato-oncology
The efficacy of low-dose transdermal fentanyl in opioid-naïve cancer patients with moderate-to-severe pain
Jung Hun Kang, Sung Yong Oh, Seo-Young Song, Hui-Young Lee, Jung Han Kim, Kyoung Eun Lee, Hye Ran Lee, In Gyu Hwang, Se Hoon Park, Won Seok Kim, Young Suk Park, Keunchil Park
Korean J Intern Med. 2015;30(1):88-95. Published online December 30, 2014
Background/Aims: Little is known about the efficacy of low-dose transdermal fentanyl (TDF) patches in opioid-naïve patients with moderate-to-severe cancer pain.
Methods: This study had an open-label, prospective design, and was conducted between April 2007 and February 2009 in seven tertiary cance..
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Infectious diseases
Prevalence and impact of extended-spectrum β-lactamase production on clinical outcomes in cancer patients with Enterobacter species bacteremia
Sun Jong Kim, Ki-Ho Park, Jin-Won Chung, Heungsup Sung, Seong-Ho Choi, Sang-Ho Choi
Korean J Intern Med. 2014;29(5):637-646. Published online August 28, 2014
Background/Aims: We examined the prevalence of extended-spectrum β-lactamase (ESBL) production and the impact of ESBL on clinical outcomes in cancer patients with Enterobacter spp. bacteremia. Methods: Using prospective cohort data on Enterobacter bacteremia obtai..
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A case of myocardial involvement in lung cancer that mimics ST segment elevation in myocardial infarction
Kye Hun Kim, Myung Ho Jeong, Hyun Ju Yoon, Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang
Korean J Intern Med. 2014;29(4):525-528. Published online June 27, 2014
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Endocrinology-metabolism
The effect of 5-aminoimidazole-4-carboxamideribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells
Won Gu Kim, Hyun-Jeung Choi, Tae Yong Kim, Young Kee Shong, Won Bae Kim
Korean J Intern Med. 2014;29(4):474-481. Published online June 27, 2014
Background/Aims: 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a cellular energy sensor that monitors intracellular AMP/adenosine triphosphate (ATP) ratios and is a key regulator of the proliferation and survival of diverse malignant cell types. In the present study, we inves..
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